Xenocide may refer to:
- Xenocide (Book), the third installment in the Ender Quartet, written by Orson Scott Card.
- Xenocide (Act), the act of committing Xenocide, the killing of an entire alien species.
- Ender the Xenocide, a nickname for Andrew Wiggin.
- First Xenocide, the close-to-annihilation of the Formics by Ender Wiggin.
- Second Xenocide, the attempted destruction of the Pequeninos and the Formics by the Lusitania Fleet, authorized by Admiral Bobby Lands.